Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approachesArticle Published on 2022-11-012022-11-15 Journal: Chemico-biological interactions [Category] SARS, 치료제, [키워드] 3D structure ACE2 addition antiparasitic approach binding binding energy caused cleavage site COVID-19 Diminazene aceturate disease drug enzyme evaluate experimental model in silico in vitro in vivo inhibit Interaction M pro membrane molecular molecular docking molecular target Prevent processed promote protease Protein Protein Data Bank PyMol reduction in S1 and S2 SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2. spike receptor-binding domain stability targets tested viral replication virus infection was used [DOI] 10.1016/j.cbi.2022.110161 PMC 바로가기
Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrenceArticle Published on 2022-10-242022-11-15 Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] COVID19(2023년), SARS, 진단, [키워드] antibody Clinical data correlated COVID-19 evaluate evaluated group healthcare worker IgG and IgM IgG antibody IgM and IgG immunoreactivity Mild symptom profile SARS-CoV-2 seroconverted serum antibody spike receptor-binding domain symptomatic Symptoms the SARS-CoV-2 were assessed were used [DOI] 10.1590/0037-8682-0106-2022 PMC 바로가기
Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5Article Published on 2022-10-132022-11-15 Journal: Cell [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 binding alveolar epithelial cell BA.2 BA.2.12.1 BA.4 BA.5 bind Characteristics COVID-19 Culture effective experiment greater hamster Health human ACE2 immune immune evasion immune resistance Immunity Infection less omicron pathogenic pathogenicity provided replicate Reproduction number risk SARS-CoV-2 spike receptor-binding domain Spread statistical analysis Substitution suggested the SARS-CoV-2 Transmissibility Transmissibility. [DOI] 10.1016/j.cell.2022.09.018 PMC 바로가기
Structural insights into the binding of SARS-CoV-2, SARS-CoV, and hCoV-NL63 spike receptor-binding domain to horse ACE2Article Published on 2022-10-062022-11-16 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome affinity Analysis B.1.617.2 Beta bind binding binding affinity cell entry complex complex structure coronavirus coronavirus Coronaviruses Delta Efficiency equine Equus functional Gamma hACE2 HCoV-NL63 HeLa cells high affinity horse human ACE2 indicated Infection infection assay molecular basis Mutation provide pseudovirus pseudovirus infection RBDs receptor Receptor binding domain receptor binding domain. Receptor-binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 variant significantly increased spike receptor-binding domain the RBD the SARS-CoV-2 the spike protein Transmission zoonotic [DOI] 10.1016/j.str.2022.07.005 PMC 바로가기
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitopeArticle Published on 2022-10-012022-11-15 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibodies antibody Antibody binding Antibody Response association competing cryo-EM Delta delta variant disrupt elicit epitope evade host immune responses hydrophobic immune evasion immune response impair inhibiting Interaction L452R Lineage mechanism Mutation neutralization omicron Population SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant spike receptor-binding domain spike variants Spread Substitution substitutions target thought variant virus entry virus variants [DOI] 10.1038/s41564-022-01235-4 PMC 바로가기
Quantitative Analysis of SARS-CoV-2 Antibody Levels in Cancer Patients Post Three Doses of Immunization and Prior to Breakthrough COVID-19 InfectionsArticle Published on 2022-09-282022-11-15 Journal: Current Oncology [Category] SARS, 변종, 진단, [키워드] Anti-spike antibody Antigen approved average AZD1222 binding antibody BNT162b2 Breakthrough infection breakthrough infections Canada Cancer cancer patient Cancer patients Concentration contagious COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine defined demonstrated dose dosed effective Effectiveness enrolled evaluate evaluated first dose hematological highest Humoral response IgG antibody Immunity immunization immunoassay indicate Infection knowledge Level MOST mRNA-1273 no difference Observed oncology participant Patient PCR polymerase chain producing prospective cohort study Protein quantified required robust antibody response robust antibody responses SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV-2 vaccination SARS-CoV-2 variants second dose Seroconversion serological response serum solid cancer spike receptor-binding domain the mean the SARS-CoV-2 vaccination Vaccine vaccine. [DOI] 10.3390/curroncol29100554 PMC 바로가기
Correlates with Vaccine Protective Capacity and COVID-19 Disease Symptoms Identified by Serum Proteomics in Vaccinated IndividualsArticle Published on 2022-09-132022-11-15 Journal: Molecules [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Algorithm allergy Analysis Asymptomatic autoantibodies autoantibody biological processes Biomarker Capacity caused characterized circulating Cohort coronavirus coronavirus disease correlated COVID-19 disease disease severity disease-associated effective intervention Efficacy epitope Evidence Genetic HBV Identified Immunoglobulin immunology implementation individual individuals mechanism non-severe cases pandemic PCR-negative PCR-positive PCR-positive individual profile Protective Protein Proteins proteomic proteomics purpura Quantitative RBD reducing response to vaccination risk SARS-CoV-2 severe disease severe symptom spike receptor-binding domain Symptom thrombosis understanding uninfected vaccinated individual Vaccine Vaccine development vaccine. virus transmission virus variant viruses with COVID-19 [DOI] 10.3390/molecules27185933 PMC 바로가기
Determinants of Neutralizing Antibody Response After SARS CoV-2 Vaccination in Patients With MyelomaArticle Published on 2022-09-102022-11-15 Journal: Journal of clinical oncology : official journal of [Category] SARS, 변종, 진단, 치료기술, [키워드] affected analyzed antibody B-cell malignancy BNT162b2 Booster vaccine Characteristics Critical Delta detect detectable determinant disease environmental exposure Factors greater hosts Immunocompromised implication increased risk induction initial lack Live virus Moderna MONITOR Mortality mRNA1273 much lower Multiple myeloma Myeloma NAb neutralization neutralize neutralizing antibody neutralizing capacity nucleocapsid Patient patients Pseudovirus neutralization assay quantified RBD receiving response SARS CoV-2 Seroconversion Serologic response significantly spike receptor-binding domain the vaccine Treatment vaccination Vaccine vaccine-induced antibody variant viral neutralization virus virus-neutralizing were measured [DOI] 10.1200/JCO.21.02257 PMC 바로가기
Structural bases for the higher adherence to ACE2 conferred by the SARS-CoV-2 spike Q498Y substitutionArticle Published on 2022-09-012022-11-16 Journal: Acta crystallographica. Section D [Category] SARS, 변종, [키워드] ACE2 ACE2 receptor addition amino-acid analysis base binding binding affinity binding kinetics circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants complex Contact contribute COVID-19 host-pathogen interactions in vitro in vivo model increase increase in Infection Interaction Lineage mice modulate mutant Mutation performed Q498Y RBD RBD-ACE2 RBD–ACE2 complex receptor ACE2 Receptor binding domain reveal SARS-CoV-2 SARS-CoV-2 variant shown Spike protein spike protein Q498Y mutation spike protein receptor binding domain. spike receptor-binding domain Substitution the binding affinity the RBD the SARS-CoV-2 the spike protein while wild-type counterpart X-ray X-ray structure [DOI] 10.1107/S2059798322007677 PMC 바로가기
Susceptibility of SARS-CoV-2 Omicron Variants to Therapeutic Monoclonal Antibodies: Systematic Review and Meta-analysisArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody Antiviral antiviral therapy clinical development Combination combinations conserved COVID-19 Critical Determining disparate effective eight eligible in vitro in vitro activity inactive interquartile range loss of activity measure median monoclonal monoclonal antibody Multidrug resistance Mutation neutralization omicron Omicron variant receptor-binding domains reduced reduction in Region reported review SARS-CoV-2 Spike protein spike protein. spike receptor-binding domain Standardization susceptibility the median the SARS-CoV-2 therapeutic treating COVID-19 variant variants wild-type [DOI] 10.1128/spectrum.00926-22 PMC 바로가기